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Reference | Country | Specimen | Marker function | Participants (Case) | Participants (Control) | |||||||||
Cancer type | Stage | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | Type | Number | Gender (M,F) | Age mean (range) (M/F) | Smoking status | ||||
Alberg et al. 2013 | US | plasma | prediagnosis | lung cancer | – | 100 | 54, 46 | 63.9 | former, current, non-smoker | healthy | 200 | 108, 92 | 63.7 | former, current, non-smoker |
Reference | Chromatography | Ion source | Positive/Negative mode | Mass analyzer | Identification level |
Alberg et al. 2013 | LC | ESI | – | – | MS/MS |
Reference | Data processing software | Database search |
Alberg et al. 2013 | – | – |
Reference | Difference method | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
Alberg et al. 2013 | – | 0.035 uM | 0.033 uM | 1.06 | 0.17 | – | – |
Reference | Classification method | Cutoff value | AUROC 95%CI | Sensitivity (%) | Specificity (%) | Accuracy (%) |
Alberg et al. 2013 | – | – | – | – | – | – |