Metabolite page

Showing information for HMDB0000929 ('tryphophan', 'L-tryptophan')

Metabolite information
HMDB ID	HMDB0000929
Synonyms	(-)-Tryptophan (2S)-2-amino-3-(1H-indol-3-yl)Propanoate (2S)-2-amino-3-(1H-indol-3-yl)Propanoic acid (L)-Tryptophan (S)-1H-Indole-3-alanine (S)-2-amino-3-(3-Indolyl)propionic acid (S)-Tryptophan (S)-a-Aminoindole-3-propionate (S)-a-Aminoindole-3-propionic acid (S)-a-amino-1H-Indole-3-propanoate (S)-a-amino-1H-Indole-3-propanoic acid (S)-a-amino-b-(3-Indolyl)-propionate (S)-a-amino-b-(3-Indolyl)-propionic acid (S)-a-amino-b-Indolepropionate (S)-a-amino-b-Indolepropionic acid (S)-alpha-Aminoindole-3-propionate (S)-alpha-Aminoindole-3-propionic acid (S)-alpha-amino-1H-Indole-3-propanoate (S)-alpha-amino-1H-Indole-3-propanoic acid (S)-alpha-amino-beta-(3-Indolyl)-propionate (S)-alpha-amino-beta-(3-Indolyl)-propionic acid (S)-alpha-amino-beta-Indolepropionate (S)-alpha-amino-beta-Indolepropionic acid (S)-α-amino-1H-indole-3-propanoate (S)-α-amino-1H-indole-3-propanoic acid (S)-α-amino-β-(3-indolyl)-propionate (S)-α-amino-β-(3-indolyl)-propionic acid 1-beta-3-Indolylalanine 1H-Indole-3-alanine 1beta-3-Indolylalanine 2-amino-3-Indolylpropanoate 2-amino-3-Indolylpropanoic acid 3-(1H-indol-3-yl)-L-Alanine 3-indol-3-Ylalanine Alpha'-amino-3-indolepropionic acid Ardeydorm Ardeypharm brand OF tryptophan Ardeytropin Esparma brand OF tryptophan H-TRP-OH ICN brand OF tryptophan Indole-3-alanine Kalma Kalma brand OF tryptophan L Tryptophan L Tryptophan ratiopharm L-(-)-Tryptophan L-Tryptofan L-Tryptophan-ratiopharm L-Tryptophane L-alpha-Aminoindole-3-propionic acid L-alpha-amino-3-Indolepropionic acid L-b-3-Indolylalanine L-beta-3-Indolylalanine L-β-3-indolylalanine Levotryptophan Lopac-T-0254 Lyphan Merck brand OF tryptophan Naturruhe Niddapharm brand OF tryptophan Optimax PMS Tryptophan PMS-Tryptophan Pacitron Pharmascience brand OF tryptophan Ratiopharm brand OF tryptophan Sedanoct Triptofano Trofan Trp Tryptacin Tryptan Tryptophan Tryptophan metabolism alterations Tryptophane Tryptophanum Upsher-smith brand OF tryptophan W alpha-Aminoindole-3-propionic acid ratio Tryptophan ratio-Tryptophan
Chemical formula	C11H12N2O2
IUPAC name	(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
CAS registry number	73-22-3
Monoisotopic molecular weight	204.089877638
Chemical taxonomy
Super class	Organoheterocyclic compounds
Class	Indoles and derivatives
Sub class	Indolyl carboxylic acids and derivatives
Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0000929 as a lung cancer biomarker

The studies that identify HMDB0000929 as a lung cancer-related metabolite

Reference	Country	Specimen	Marker function	Participants (Case)						Participants (Control)
Reference	Country	Specimen	Marker function	Cancer type	Stage	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status	Type	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status
Hori et al. 2011	Japan	tissue	diagnosis	adenocarcinoma, squamous cell carcinoma, SCLC	–	7	6, 1	median: 61 (53-82)	smoker, non-smoker	tumor vs. adjacent normal tissue	7	6, 1	median: 61 (53-82)	smoker, non-smoker
Qi et al. 2021	China	blood	diagnosis	adenocarcinoma, squamous cell carcinoma, small cell lung cancer, other types, unknown types	I, II, III, IV	98	51, 47	Median: 50 (32-69)	–	healthy	75	36, 39	Median: 50 (31-69)	–
Kowalczyk et al. 2021	Poland	Tissue	diagnosis	adenocarcinoma (ADC)	I, II, III	33	23, 10	64.77 ± 8.44	–	healthy control	20	13, 7	61.5 ± 12.06	–
Kowalczyk et al. 2021	Poland	Tissue	diagnosis	squemous cell carcinoma (SCC)	I, II, III	54	39, 15	64.45 ± 8.02	–	healthy control	20	13, 7	61.5 ± 12.06	–

Reference	Chromatography	Ion source	Positive/Negative mode	Mass analyzer	Identification level
Hori et al. 2011	GC	–	–	–	–
Qi et al. 2021	LC	ESI	both	Q-Orbitrap	MS/MS
Kowalczyk et al. 2021	LC	ESI	both	Q-TOF	–
Kowalczyk et al. 2021	LC	ESI	both	Q-TOF	–

Reference	Data processing software	Database search
Hori et al. 2011	Shimadzu GCMSsolution software	commercially available GC/MS Metabolite Mass Spectral Database (Shimadzu Co.), NIST Mass Spectral Library (NIST 08)
Qi et al. 2021	ProteoWizard, XCMS, Xcalibur, CAMERA	mzCloud, ChemSpider, LipidBlast and Fiehn HILIC
Kowalczyk et al. 2021	Mass Hunter Qualitative Analysis Software, Mass Profiler Professional	METLIN, KEGG, LIPIDMAPS, and HMDB
Kowalczyk et al. 2021	Mass Hunter Qualitative Analysis Software, Mass Profiler Professional	METLIN, KEGG, LIPIDMAPS, and HMDB

Differential analysis
Classification analysis

Reference	Difference method	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
Hori et al. 2011	student’s t-test, PLS-DA	–	–	4.43	0.02	–	–
Qi et al. 2021	PCA, OPLS-DA, Student’s t test	–	–	0.92	0.01	–	4.29
Kowalczyk et al. 2021	Mann–Whitney U-test and Benjamini–Hochberg false discovery rate, partial least squares discriminant analysis (PLS-DA)	–	–	–	2.25e-06	–	–
Kowalczyk et al. 2021	Mann–Whitney U-test and Benjamini–Hochberg false discovery rate, partial least squares discriminant analysis (PLS-DA)	–	–	–	2.92e-06	–	–

Reference	Classification method	Cutoff value	AUROC 95%CI	Sensitivity (%)	Specificity (%)	Accuracy (%)
Hori et al. 2011	–	–	–	–	–	–
Qi et al. 2021	–	–	–	–	–	–
Kowalczyk et al. 2021	–	–	–	–	–	–
Kowalczyk et al. 2021	–	–	–	–	–	–