Showing information for HMDB0001413 ("cytidine 5'-diphosphocholine")

Metabolite information
HMDB ID HMDB0001413
Synonyms
5'-Diphosphocholine, cytidine
Audes
CDP Choline
CDP-Choline
CDP-Colina
Cereb
Choline 5'-cytidine diphosphate
Choline cytidine diphosphate
Choline, CDP
Choline, cytidine diphosphate
Cidifos
Citicholine
Citicolina
Citicolinum
Citidin difosfato de colina
Citidoline
Citifar
Colite
Corenalin
Cyscholin
Cyticholine
Cytidindiphosphocholin
Cytidine 5' diphosphocholine
Cytidine 5'-(choline diphosphate)
Cytidine 5'-(choline diphosphoric acid)
Cytidine 5'-(cholinyl pyrophosphate)
Cytidine 5'-(cholinyl pyrophosphoric acid)
Cytidine 5'-diphosphate choline
Cytidine 5'-diphosphocholine
Cytidine 5'-diphosphoric choline
Cytidine 5-diphosphate-trihydrogen
Cytidine choline diphosphate
Cytidine diphosphate choline
Cytidine diphosphate choline ester
Cytidine diphosphocholine
Cytidine diphosphorylcholine
Cytidine-5' diphosphocholine
Cytidine-5'-pyrophosphate-hydroxycholine
Cytidoline
Difosfocin
Diphosphate choline, cytidine
Emicholine F
Ensign
Haocolin
Hornbest
Neucolis
Nicholin
Nicolin
Niticolin
P-Hydroxide[2-(trimethylammonio)ethyl] ester
Reagin
Recofnan
Recognan
Rexort
Sintoclar
Somazina
Somazine
Suncholin
[2-CYTIDYLATE-o'-phosphonyloxyl]-ethyl-trimethyl-ammonium
[2-CYTIDYLic acid-o'-phosphonyloxyl]-ethyl-trimethyl-ammonium
Chemical formula C14H26N4O11P2
IUPAC name
{2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)oxy]ethyl}trimethylazanium
CAS registry number 987-78-0
Monoisotopic molecular weight 488.107330718

Chemical taxonomy
Super class Nucleosides, nucleotides, and analogues
Class Pyrimidine nucleotides
Sub class Pyrimidine ribonucleotides

Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0001413 as a lung cancer biomarker

The studies that identify HMDB0001413 as a lung cancer-related metabolite

Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
Moreno et al. 2018 Spain tissue therapy, diagnosis squamous cell carcinoma I, II, III 35 35, 0 68.71 ± 7.46 – tumor vs. adjacent normal tissue 35 35, 0 68.71 ± 7.46 –
Moreno et al. 2018 Spain tissue therapy, diagnosis adenocarcinoma I, II, III 33 24, 9 62.11 ± 9.73 – tumor vs. adjacent normal tissue 33 24, 9 62.11 ± 9.73 –
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Reference Data processing software Database search
Moreno et al. 2018 – KEGG, HMDB
Moreno et al. 2018 – KEGG, HMDB
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
Moreno et al. 2018 paired two-sample t-test, PLS-DA – – 14.96 5.03e-17 5.02e-15 –
Moreno et al. 2018 paired two-sample t-test, PLS-DA – – 4.47 2.48e-14 9.09e-12 –
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
Moreno et al. 2018 – – – – – –
Moreno et al. 2018 – – – – – –