Metabolite page

Showing information for HMDB0006049 ('o-phosphotyrosine')

Metabolite information
HMDB ID	HMDB0006049
Synonyms	L-3-(4-Hydroxyphenyl)alanine 4'-phosphate L-Phosphotyrosine L-Tyrosine-O-phosphate O-phospho-L-Tyrosine O-phosphono-L-Tyrosine Phosphonotyrosine Phosphotyrosine Phosphotyrosine (py) Tyrosine O phosphate Tyrosine O-phosphate Tyrosine phosphate Tyrosine phosphoric acid Tyrosine-O-phosphate phospho-L-Tyrosine
Chemical formula	C9H12NO6P
IUPAC name	(2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid
CAS registry number	–
Monoisotopic molecular weight	261.040223633
Chemical taxonomy
Super class	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Sub class	Amino acids, peptides, and analogues
Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0006049 as a lung cancer biomarker

Wu et al. 2014;

The studies that identify HMDB0006049 as a lung cancer-related metabolite

Reference	Country	Specimen	Marker function	Participants (Case)						Participants (Control)
Reference	Country	Specimen	Marker function	Cancer type	Stage	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status	Type	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status
Wu et al. 2014	China	urine	diagnosis	NSCLC	–	20	10, 10	38-74	–	healthy	20	10, 10	35-66	–

Reference	Chromatography	Ion source	Positive/Negative mode	Mass analyzer	Identification level
Wu et al. 2014	LC	ESI	negative	Q-TOF	MS/MS

Reference	Data processing software	Database search
Wu et al. 2014	MassLynx	HMDB, metlin, lipidmaps

Differential analysis
Classification analysis

Reference	Difference method	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
Wu et al. 2014	OPLS-DA, student’s t-test	–	–	1.49	0.02	–	2.31

Reference	Classification method	Cutoff value	AUROC 95%CI	Sensitivity (%)	Specificity (%)	Accuracy (%)
Wu et al. 2014	ROC curve analysis	–	–	–	–	–