Showing information for HMDB0000912 ('succinyladenosine', 'N6-succinyladenosine')

Metabolite information
HMDB ID HMDB0000912
Synonyms
(S)-N-(1,2-Dicarboxyethyl)-adenosine
6-(1,2-dicarboxyethylamino)-9-b-D-Ribofuranosylpurine
6-(1,2-dicarboxyethylamino)-9-beta-D-Ribofuranosylpurine
6-(1,2-dicarboxyethylamino)-9-beta-delta-Ribofuranosylpurine
6-(1,2-dicarboxyethylamino)-9-β-D-ribofuranosylpurine
N-(9-b-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartate
N-(9-b-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartic acid
N-(9-beta-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartate
N-(9-beta-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartic acid
N-(9-beta-delta-Ribofuranosyl-9H-purin-6-yl)-L-aspartate
N-(9-beta-delta-Ribofuranosyl-9H-purin-6-yl)-L-aspartic acid
N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-L-aspartate
N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-L-aspartic acid
N-9-Ribofuranosyl-9H-purin-6-yl-aspartate
N-9-Ribofuranosyl-9H-purin-6-yl-aspartic acid
Succinoadenosine
Chemical formula C14H17N5O8
IUPAC name
(2S)-2-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)butanedioic acid
CAS registry number 4542-23-8
Monoisotopic molecular weight 383.107712545

Chemical taxonomy
Super class Nucleosides, nucleotides, and analogues
Class Purine nucleosides
Sub class –

Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0000912 as a lung cancer biomarker

The studies that identify HMDB0000912 as a lung cancer-related metabolite

Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
An et al. 2010 China urine diagnosis adenocarcinoma, squamous cell carcinoma, SCLC – 19 – 61 ± 8.4 – healthy 22 – – –
Moreno et al. 2018 Spain tissue therapy, diagnosis squamous cell carcinoma I, II, III 35 35, 0 68.71 ± 7.46 – tumor vs. adjacent normal tissue 35 35, 0 68.71 ± 7.46 –
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
An et al. 2010 LC ESI positive Q-TOF MS/MS
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Reference Data processing software Database search
An et al. 2010 MZmine 2 beta HMDB, PubChem compound database, METLIN, KEGG
Moreno et al. 2018 – KEGG, HMDB
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
An et al. 2010 independent t-test – – – 0.02 – –
Moreno et al. 2018 paired two-sample t-test, PLS-DA – – 2.40 4.54e-09 1.84e-08 –
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
An et al. 2010 – – – – – –
Moreno et al. 2018 – – – – – –