Showing information for HMDB0029068 ('threonylphenylalanine')

Metabolite information
HMDB ID HMDB0029068
Synonyms
L-Threoninyl-L-phenylalanine
T-F Dipeptide
TF Dipeptide
THR-Phe
Threonine phenylalanine dipeptide
Threonine-phenylalanine dipeptide
Threoninylphenylalanine
Chemical formula C13H18N2O4
IUPAC name
2-(2-amino-3-hydroxybutanamido)-3-phenylpropanoic acid
CAS registry number –
Monoisotopic molecular weight 266.126657074

Chemical taxonomy
Super class Organic acids and derivatives
Class Carboxylic acids and derivatives
Sub class Amino acids, peptides, and analogues

Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0029068 as a lung cancer biomarker

The studies that identify HMDB0029068 as a lung cancer-related metabolite

Reference Country Specimen Marker function Participants (Case) Participants (Control)
Cancer type Stage Number Gender (M,F) Age mean (range) (M/F) Smoking status Type Number Gender (M,F) Age mean (range) (M/F) Smoking status
Moreno et al. 2018 Spain tissue therapy, diagnosis squamous cell carcinoma I, II, III 35 35, 0 68.71 ± 7.46 – tumor vs. adjacent normal tissue 35 35, 0 68.71 ± 7.46 –
Moreno et al. 2018 Spain tissue therapy, diagnosis adenocarcinoma I, II, III 33 24, 9 62.11 ± 9.73 – tumor vs. adjacent normal tissue 33 24, 9 62.11 ± 9.73 –
Reference Chromatography Ion source Positive/Negative mode Mass analyzer Identification level
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Moreno et al. 2018 LC, GC ESI, EI both LC: linear ion-trap, GC: single-quadrupole LC: MS/MS
Reference Data processing software Database search
Moreno et al. 2018 – KEGG, HMDB
Moreno et al. 2018 – KEGG, HMDB
Reference Difference method Mean concentration (case) Mean concentration (control) Fold change (case/control) P-value FDR VIP
Moreno et al. 2018 paired two-sample t-test, PLS-DA – – 10.36 5.67e-14 1.17e-12 –
Moreno et al. 2018 paired two-sample t-test, PLS-DA – – 1.57 1.86e-03 4.36e-03 –
Reference Classification method Cutoff value AUROC 95%CI Sensitivity (%) Specificity (%) Accuracy (%)
Moreno et al. 2018 – – – – – –
Moreno et al. 2018 – – – – – –