Metabolite page

Showing information for HMDB0001940 ('triamterene')

Metabolite information
HMDB ID	HMDB0001940
Synonyms	6-Phenyl-2,4,7-triaminopteridine Ademin Ademine Diren Ditak Diurene Dyren Dyrenium Dytac Goldshield brand OF triamterene Jatropur Jorba brand OF triamterene Noridil Noridyl Pterofen Pterophene SmithKline beecham brand OF triamterene Taturil Teriam Teridin Tri-span Triampur Triamteren Triamteril Triamteril complex Trispan Triteren Urocaudal Wellspring brand OF triamterene
Chemical formula	C12H11N7
IUPAC name	6-phenylpteridine-2,4,7-triamine
CAS registry number	396-01-0
Monoisotopic molecular weight	253.107593387
Chemical taxonomy
Super class	Organoheterocyclic compounds
Class	Pteridines and derivatives
Sub class	–
Biological properties
Pathways (Pathway Details in HMDB)

The paper(s) that report HMDB0001940 as a lung cancer biomarker

The studies that identify HMDB0001940 as a lung cancer-related metabolite

Reference	Country	Specimen	Marker function	Participants (Case)						Participants (Control)
Reference	Country	Specimen	Marker function	Cancer type	Stage	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status	Type	Number	Gender (M,F)	Age mean (range) (M/F)	Smoking status
Mazzone et al. 2016	US	serum	–	adenocarcinoma, squamous cell carcinoma	I, II, III	94	55.3%, 44.7%	68.7	–	at-risk controls	190	50.5%, 49.5%	66.2	–

Reference	Chromatography	Ion source	Positive/Negative mode	Mass analyzer	Identification level
Mazzone et al. 2016	LC	ESI	positive	linear ion-trap	MS/MS

Reference	Data processing software	Database search
Mazzone et al. 2016	Metabolon LIMS system	Metabolon LIMS system

Differential analysis
Classification analysis

Reference	Difference method	Mean concentration (case)	Mean concentration (control)	Fold change (case/control)	P-value	FDR	VIP
Mazzone et al. 2016	two- sample independent t test	0.156± 0	0.1959789± 0.2169353	0.80	0.08	0.15	–

Reference	Classification method	Cutoff value	AUROC 95%CI	Sensitivity (%)	Specificity (%)	Accuracy (%)
Mazzone et al. 2016	–	–	–	–	–	–