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Citation Information
Int J Cancer. 2010 Jun 1;126(11):2663-70. doi: 10.1002/ijc.24970.
Breath gas aldehydes as biomarkers of lung cancer.
Fuchs P, Loeseken C, Schubert JK, Miekisch W.
Analytical methods | |||
|---|---|---|---|
| Comparative study | #1 | #2 | |
| Chromatography | GC | GC | |
| Ion source | EI | EI | |
| Positive/Negative mode | – | – | |
| Mass analyzer | – | – | |
| Identification level | – | – | |
Sample information | |||
|---|---|---|---|
| Comparative study | #1 | #2 | |
| Country | Germany | Germany | |
| Specimen | exhaled breath | exhaled breath | |
| Marker function | diagnosis | diagnosis | |
| Participants(Case) | Cancer type | NSCLC, SCLC | NSCLC, SCLC |
| Stage | – | – | |
| Number | 12 | 12 | |
| Gender (M,F) | 11, 1 | 11, 1 | |
| Mean age (range) (M,F) | – | – | |
| Smoking status | – | – | |
| Participants(Control) | Type | healthy | healthy |
| Number | 24 | 24 | |
| Gender (M,F) | 10, 14 | 10, 14 | |
| Mean age (range) (M,F) | – | – | |
| Smoking status | smoker, non-smoker | smoker, non-smoker | |
Data processing and metabolite identification | |
|---|---|
| Data processing software | – |
| Database search | – |
Statistical analysis | |
|---|---|
| Differential analysis method | – |
| Classification method | – |
| Survival analysis method | – |
Lung cancer-related metabolites identified in the paper
| Metabolite | Author-emphasized biomarkers | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
|---|---|---|---|---|---|---|---|
| nonanal | – | – | – | – | 0.03 | – | – |
| octanal | – | – | – | – | 0.01 | – | – |
| hexanal | – | – | – | – | 6.00e-03 | – | – |
| pentanal | – | – | – | – | 1.00e-03 | – | – |
| CEA | – | – | – | – | – | – | – |
| CYFRA 21-1 | – | – | – | – | – | – | – |
| NSE | – | – | – | – | – | – | – |
| Metabolite | Author-emphasized biomarkers | Cutoff value | AUROC (95%CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
| nonanal | – | 8.433 nmol/L | – | 33.3 | 95.8 | – |
| octanal | – | 1.068 nmol/L | – | 58.3 | 91.7 | – |
| hexanal | – | 1.208 nmol/L | – | 8.3 | 91.7 | – |
| pentanal | – | 0.275 nmol/L | – | 75 | 95.8 | – |
| CEA | – | 5.61 ng/mL | – | 58.3 | 95.7 | – |
| CYFRA 21-1 | – | 3.34 ng/mL | – | 66.7 | 100 | – |
| NSE | – | 22.85 ng/mL | – | 50 | 91.3 | – |
Paper graphical summary
