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Citation Information
Eur J Cancer Prev. 2013 Jul;22(4):335-41. doi: 10.1097/CEJ.0b013e32835b3898.
Blood plasma metabolites and the risk of developing lung cancer in Russia.
Lokhov PG, Trifonova OP, Maslov DL, Archakov AI.
Analytical methods | ||
|---|---|---|
| Comparative study | #1 | |
| Chromatography | DI | |
| Ion source | ESI | |
| Positive/Negative mode | both | |
| Mass analyzer | Q-TOF | |
| Identification level | – | |
Sample information | ||
|---|---|---|
| Comparative study | #1 | |
| Country | Russia | |
| Specimen | plasma | |
| Marker function | diagnosis | |
| Participants(Case) | Cancer type | lung cancer |
| Stage | I, II, III, IV | |
| Number | 100 | |
| Gender (M,F) | 88, 12 | |
| Mean age (range) (M,F) | median: 60 (44-76) | |
| Smoking status | smoker, non-smoker | |
| Participants(Control) | Type | healthy |
| Number | 100 | |
| Gender (M,F) | 89, 11 | |
| Mean age (range) (M,F) | median: 59 (37-71) | |
| Smoking status | smoker, non-smoker | |
Data processing and metabolite identification | |
|---|---|
| Data processing software | DataAnalysis |
| Database search | Human Metabolome Database, Metlin Database, NIST Chemistry WebBook Database |
Statistical analysis | |
|---|---|
| Differential analysis method | odds ratio |
| Classification method | – |
| Survival analysis method | – |
Lung cancer-related metabolites identified in the paper
| Metabolite | Author-emphasized biomarkers | Mean concentration (case) | Mean concentration (control) | Fold change (case/control) | P-value | FDR | VIP |
|---|---|---|---|---|---|---|---|
| biotin sulfone | V | – | – | – | – | – | – |
| halfenprox | V | – | – | – | – | – | – |
| permethrin | V | – | – | – | – | – | – |
| R-benzene | V | – | – | – | – | – | – |
| Metabolite | Author-emphasized biomarkers | Cutoff value | AUROC (95%CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
| biotin sulfone | V | – | – | – | – | – |
| halfenprox | V | – | – | – | – | – |
| permethrin | V | – | – | – | – | – |
| R-benzene | V | – | – | – | – | – |
Paper graphical summary
